Eyes

In some COVID-19 patients, SARS-CoV-2 might have entered the eyes of those who had not been wearing face shields (Lu CW et al.). Some patients had prodromal ocular symptoms (irritation, conjunctivitis) before onset of disease in other body parts (Hong et al.). RT-PCR found SARS-CoV-2 in the tears and conjunctival secretions of some patients with dry eyes and conjunctivitis (Aiello et al.; Chen L, Liu M et al.; Chen MJ et al.; Wu P et al.; Xia et al.; Zhang X et al.), and some patients without eye symptoms (Xie et al.). Sars-CoV-2 replicates competently in conjunctiva (Hui et al.) The flow of tears to the nasolacrimal system, and the innate immune system, can prevent most pathogens from entering the eyes. But if SARS-CoV-2 gets past that, and infect some eyes cells via their ACE2 receptors (Zhou et al.), then viruses could flush with tears into the nasopharyngeal space, and then to the respiratory system (Hong et al.; Napoli et al.). For these reasons, COVID-19 might be transmitted from an infected person’s eye to others. So, people in general should avoid touching near their eyes, and people near COVID-19 patients should wear face shields or goggles (Chen MJ et al.; Lu et al.; Napoli et al.; Wu P et al.).